Statins Enhance Rotator Cuff Healing by Stimulating the COX2/PGE2/EP4 Pathway

@article{Dolkart2014StatinsER,
  title={Statins Enhance Rotator Cuff Healing by Stimulating the COX2/PGE2/EP4 Pathway},
  author={Oleg Dolkart and Tamar Liron and Ofir Chechik and Dalia Somjen and Tamar Brosh and Eran Maman and Yankel Gabet},
  journal={The American Journal of Sports Medicine},
  year={2014},
  volume={42},
  pages={2869 - 2876}
}
Background: Statins are lipid-lowering drugs with many beneficial pleiotropic effects. Cyclooxygenase (COX2) selective inhibitors that are commonly prescribed in orthopaedic patients may effect healing. Evidence indicates that statins stimulate COX2 activity. Hypothesis: Atorvastatin (ATV) administration will enhance tendon healing by stimulating the acute inflammatory phase via increasing the production of prostaglandin E2 (PGE2). Study Design: Controlled laboratory study. Methods: After… Expand
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