Statins Decrease Neuroinflammation and Prevent Cognitive Impairment after Cerebral Malaria

@inproceedings{Reis2012StatinsDN,
  title={Statins Decrease Neuroinflammation and Prevent Cognitive Impairment after Cerebral Malaria},
  author={Patr{\'i}cia Alves Reis and Vanessa Estato and Tathiany I. da Silva and Joana Costa Pinto d'Avila and Luciana Domett Siqueira and Edson Fernandes de Assis and Patr{\'i}cia Torres Bozza and Fernando A Bozza and Eduardo Tibirica and Guy A. Zimmerman and Hugo Caire de Castro-Faria-Neto},
  booktitle={PLoS pathogens},
  year={2012}
}
Cerebral malaria (CM) is the most severe manifestation of Plasmodium falciparum infection in children and non-immune adults. Previous work has documented a persistent cognitive impairment in children who survive an episode of CM that is mimicked in animal models of the disease. Potential therapeutic interventions for this complication have not been investigated, and are urgently needed. HMG-CoA reductase inhibitors (statins) are widely prescribed for cardiovascular diseases. In addition to… CONTINUE READING
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