Statin use is associated with enhanced collateralization of severely diseased coronary arteries.

@article{Pourati2003StatinUI,
  title={Statin use is associated with enhanced collateralization of severely diseased coronary arteries.},
  author={Isaac Pourati and Carey Kimmelstiel and William Rand and Richard H Karas},
  journal={American heart journal},
  year={2003},
  volume={146 5},
  pages={876-81}
}
BACKGROUND The presence of coronary collateral vessels has been associated with improved clinical outcome in patients with coronary artery disease. Animal experiments have shown that hydroxymethyl glutaryl coenzyme A reductase inhibitors (statins) can promote angiogenesis in ischemic tissues in a cholesterol-independent manner. We hypothesized that statin therapy is associated with increased coronary collateral formation in patients with severe coronary artery disease. METHODS AND RESULTS… CONTINUE READING