Statin use has negative clinical impact on non-germinal center in patients with diffuse large B cell lymphoma in rituximab era.

@article{Song2015StatinUH,
  title={Statin use has negative clinical impact on non-germinal center in patients with diffuse large B cell lymphoma in rituximab era.},
  author={M G Song and J S Chung and Gyeong-Won Lee and Su-Hee Cho and Junshik Hong and Dong-Yeop Shin and H K Shin},
  journal={Leukemia research},
  year={2015},
  volume={39 2},
  pages={211-5}
}
Rituximab improved prognosis in diffuse large B cell lymphoma (DLBCL). However, activity of rituximab may be reduced by conformational change in CD20 by statin-induced cholesterol depletion. Conformation change in CD20 could impair the binding of rituximab and significantly decrease the killing effect of lymphoma cells. R-CHOP therapy could counteract the prognostic gap between GC type and non-GC type. We investigated whether statin use could have different clinical impacts on… CONTINUE READING