Statin use and the risk of developing diabetes: a network meta‐analysis

@article{Thakker2016StatinUA,
  title={Statin use and the risk of developing diabetes: a network meta‐analysis},
  author={Divyesh Thakker and Sunita R. Nair and Amit Pagada and Vinayak Sudhir Jamdade and Anuradha Malik},
  journal={Pharmacoepidemiology and Drug Safety},
  year={2016},
  volume={25},
  pages={1131 - 1149}
}
Randomized controlled trials have shown mixed findings regarding the association of statins and diabetes. This systematic literature review and network meta‐analysis (NMA) was performed to update evidence on this association to possibly assist clinicians in making more informed treatment choices. 
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81 Citations
Background Citations
20
Methods Citations
1
Results Citations
4

81 Citations

Statin users have an elevated risk of dysglycemia and new‐onset‐diabetes
TLDR
This work sought to understand the risk of dysglycemia and NOD for a cohort of individuals that reflect real‐world physician prescribing patterns and identify patients at risk of new‐onset‐diabetes development.
Associations of statin use with glycaemic traits and incident type 2 diabetes
TLDR
This study aimed to investigate the association of statin use with glycaemic traits and incident type 2 diabetes.
Statins are associated with new onset type 2 diabetes mellitus (T2DM) in Medicare patients ≥65 years
TLDR
To evaluate the association of statins and co‐morbidities with new onset type 2 diabetes mellitus (T2DM) in patients 65 years and older, a large number of patients with T2DM are enrolled.
Statin use and risk of new-onset diabetes: A meta-analysis of observational studies.
Statins and diabetes: focus on pitavastatin
TLDR
Particular attention is paid to the place of pitavastatin, due to its low diabetogenicity and minimal risk of drug interactions, as well as the need of taking into consideration the risk factors of diabetes and the preventive measures in patients receiving statin therapy.
The Challenge: Finding the Most Appropriate Statin and Dose for Each Patient.
  • J. Lillo
  • Medicine, Psychology
    The Journal of family practice
  • 2021
TLDR
The nocebo effect is a common reason for perceived statin intolerance and several strategies are available that can enable continuation of statin therapy in patients who are truly statin-intolerant.
Statin use and risk of developing diabetes: results from the Diabetes Prevention Program
TLDR
In this population at high risk for diabetes, the authors observed significantly higher rates of diabetes with statin therapy in all three treatment groups, and the effect of statins to increase diabetes risk appears to extend to populations at highrisk for diabetes.
Statin use and safety concerns: an overview of the past, present, and the future
TLDR
The most common adverse effects of statins are described, available evidence is examined and the role of ethnicity, lipophilicity and other biological factors that could mediate and/or influence the relationship are highlighted.
Association between statin treatment and new-onset diabetes mellitus: a population based case–control study
TLDR
The risk of NODM was not associated with an increase in the cumulative duration of statin use or with non-recent use, and only recent short-term use of cholesterol-lowering statin was associated with a increased risk ofNODM.
Diabetes Caused by Statin Use: A Review
TLDR
Many studies have concluded that Pitavastatin and pravastatinom do not affect glycemic control and may be a beneficial treatment option in patients with, or at risk for, type 2 diabetes.
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