Statin use and risk of gallstone disease: A meta‐analysis

  title={Statin use and risk of gallstone disease: A meta‐analysis},
  author={He-ping Kan and Wen-bin Guo and Yong-fa Tan and Jie Zhou and Cundong Liu and Yu-Qi Huang},
  journal={Hepatology Research},
  pages={942 - 948}
There is emerging evidence from animal and human studies that current statins can decrease the formation of gallbladder cholesterol gallstones and subsequently decrease the risk of gallstone disease, but consistent results have not been reported. We performed a meta‐analysis to provide an overview of the relevant studies. 

Gallstone Disease: Scientific Understanding and Future Treatment

Later in the twenty first century, general lifestyle interventions and precise molecular prevention might overcome the current invasive therapy of gallstone disease with cholecystectomy.

Statins affect gallstone diseases: Underlying mechanism(s) are to be established

  • S. Tazuma
  • Medicine, Biology
    Hepatology research : the official journal of the Japan Society of Hepatology
  • 2015
Current statin users had a decreased odds ratio for gallstone disease compared with non-users, and there was a tendency toward a lower OR for high-dose compared with low-dose exposure, which can deduce that the management of lipid metabolism plays a role in therapeutic strategy for cholesterol gallstones disease.

Association of Statin Therapy and Risks of Cholelithiasis, Biliary Tract Diseases, and Gallbladder Procedures

Statin use was not significantly associated with either an increased or decreased risk of cholelithiasis or gallbladder disease among statin users compared with nonusers in an American patient cohort.

Alcohol consumption and risk of gallstone disease: a meta-analysis

This meta-analysis suggests that alcohol consumption is associated with significantly decreased risk of gallstone disease.

Clinical Practice Guidelines on the prevention , diagnosis and treatment of gallstones q European Association for the Study of the Liver ( EASL ) ⇑

The EASL Clinical Practice Guidelines (CPG) on the prevention, diagnosis and therapy of gallstones aim to provide current recommendations on the following issues.

New determinants for gallstone disease?

All of the identified determinants for incident gallstone disease can be linked to the three biological mechanisms of gallstone formation, and future clinical or larger population-based interventional trials aiming at changing body weight, circulating levels of non-HDL cholesterol, or alcohol consumption are supported.

Statin use and risk of cholecystectomy – A case-control analysis using Swiss claims data

The study supports the previously raised hypothesis that long-term statin use reduces the risk of cholecystectomy and adjusts the analyses for history of cardiovascular diseases and for use of estrogens, fibrates and other lipid-lowering agents.

Incidence of gallstone disease and complications

Because of the absence of effective gallstone formation prevention, targets against the metabolic changes in obesity should be further explored in randomized controlled trials.

Are incident gallstones associated to sex‐dependent changes with age? A cohort study

Changes with age in alcohol consumption in females and in reproductive hormones determined incident gallstones, and male reproductive hormones seem to have an impact on incidentgallstones.



Meta‐analysis of alcohol consumption and risk of extrahepatic bile system cancer

A meta‐analysis is performed to provide an overview of the relevant studies and gain more robust estimates of the relationship between alcohol consumption and risk of EBSC.

Gallbladder disease in the general population: association with cardiovascular morbidity and therapy

Evaluated different cardiovascular conditions and related drugs that could be associated with gallbladder disease and found that thiazide diuretics may also be a risk factor for this condition.

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  • R. Dowling
  • Medicine
    Alimentary pharmacology & therapeutics
  • 2000
The aim of this article is to review selected aspects of the pathogenesis of cholesterol‐rich, gall‐bladder stones (GBS) – with emphasis on recent developments in biliary cholesterol saturation,

Statin use and risk of gallstone disease followed by cholecystectomy.

Long-term use of statins was associated with a decreased risk of gallstone disease followed by cholecystectomy, and exposure to lipid-lowering agents was stratified by exposure timing and duration.

Long-term statin use and the risk of gallstone disease: A population-based case-control study.

A population-based case-control study using medical databases from northern Denmark to identify 32,494 cases of gallstones occurring between 1996 and 2008 and to identify age, sex, and county-matched population controls for each case found the use of statin use showed no similar association with gallstone disease.

Statin use and the risk of cholecystectomy in women.

Statin use appears to reduce the risk of cholecystectomy in women, according to a retrospective analysis of statin use from 1994 forward and a prospective analysis for general lipid-lowering drugs from 1994 to 2004.

Statin use and the risk of gallstone disease: a population-based case–control study

This study does not provide support for a beneficial association between usage of statin and gallstone disease.

Statins as potential treatment for cholesterol gallstones: an attempt to understand the underlying mechanism of actions

Statins, widely used in prevention of CVD and hypercholesteremia, have been shown to dissolve cholesterol gallstones in animal models and human studies, highlighting the potential for a pharmacological therapy for gallstones.

Role of diet in cholesterol gallstone formation.

Statin administration and risk of cholecystectomy: a population-based case-control study

The results of a large population-based study suggest that the use of statins reduces the risk of surgery for gallstone disease.