Statin use and risk of gallstone disease: A meta‐analysis

@article{Kan2015StatinUA,
  title={Statin use and risk of gallstone disease: A meta‐analysis},
  author={He-ping Kan and Wen-bin Guo and Yong-fa Tan and Jie Zhou and Cundong Liu and Yu-Qi Huang},
  journal={Hepatology Research},
  year={2015},
  volume={45},
  pages={942 - 948}
}
There is emerging evidence from animal and human studies that current statins can decrease the formation of gallbladder cholesterol gallstones and subsequently decrease the risk of gallstone disease, but consistent results have not been reported. We performed a meta‐analysis to provide an overview of the relevant studies. 

Gallstone Disease: Scientific Understanding and Future Treatment

Later in the twenty first century, general lifestyle interventions and precise molecular prevention might overcome the current invasive therapy of gallstone disease with cholecystectomy.

Statins affect gallstone diseases: Underlying mechanism(s) are to be established

  • S. Tazuma
  • Medicine, Biology
    Hepatology research : the official journal of the Japan Society of Hepatology
  • 2015
Current statin users had a decreased odds ratio for gallstone disease compared with non-users, and there was a tendency toward a lower OR for high-dose compared with low-dose exposure, which can deduce that the management of lipid metabolism plays a role in therapeutic strategy for cholesterol gallstones disease.

Association of Statin Therapy and Risks of Cholelithiasis, Biliary Tract Diseases, and Gallbladder Procedures

Statin use was not significantly associated with either an increased or decreased risk of cholelithiasis or gallbladder disease among statin users compared with nonusers in an American patient cohort.

Alcohol consumption and risk of gallstone disease: a meta-analysis

This meta-analysis suggests that alcohol consumption is associated with significantly decreased risk of gallstone disease.

Clinical Practice Guidelines on the prevention , diagnosis and treatment of gallstones q European Association for the Study of the Liver ( EASL ) ⇑

The EASL Clinical Practice Guidelines (CPG) on the prevention, diagnosis and therapy of gallstones aim to provide current recommendations on the following issues.

New determinants for gallstone disease?
.

All of the identified determinants for incident gallstone disease can be linked to the three biological mechanisms of gallstone formation, and future clinical or larger population-based interventional trials aiming at changing body weight, circulating levels of non-HDL cholesterol, or alcohol consumption are supported.

Statin use and risk of cholecystectomy – A case-control analysis using Swiss claims data

The study supports the previously raised hypothesis that long-term statin use reduces the risk of cholecystectomy and adjusts the analyses for history of cardiovascular diseases and for use of estrogens, fibrates and other lipid-lowering agents.

Incidence of gallstone disease and complications

Because of the absence of effective gallstone formation prevention, targets against the metabolic changes in obesity should be further explored in randomized controlled trials.

Are incident gallstones associated to sex‐dependent changes with age? A cohort study

Changes with age in alcohol consumption in females and in reproductive hormones determined incident gallstones, and male reproductive hormones seem to have an impact on incidentgallstones.

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