Statin use and non-alcoholic steatohepatitis in at risk individuals.

  title={Statin use and non-alcoholic steatohepatitis in at risk individuals.},
  author={Paola Dongiovanni and Salvatore Petta and Ville Mannisto and Rosellina Margherita Mancina and Rosaria Maria Pipitone and Vesa Karja and Marco Maggioni and Pirjo Kakela and Olov Wiklund and E. Mozzi and Stefania Grimaudo and Dorota Kaminska and Raffaela Rametta and Antonio Crax{\`i} and Silvia Fargion and Valerio Nobili and S Romeo and Jussi Pihlajamaki and Luca Valenti},
  journal={Journal of hepatology},
  volume={63 3},
BACKGROUND & AIMS Excess hepatic free cholesterol contributes to the pathogenesis of non-alcoholic steatohepatitis, and statins reduce cholesterol synthesis. Aim of this study was to assess whether statin use is associated with histological liver damage related to steatohepatitis. METHODS The relationship between statin use, genetic risk factors, and liver damage was assessed in a multi-center cohort of 1201 European individuals, who underwent liver biopsy for suspected non-alcoholic… CONTINUE READING
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