Statin therapy interacts with cytomegalovirus seropositivity and high C-reactive protein in reducing mortality among patients with angiographically significant coronary disease.

@article{Horne2003StatinTI,
  title={Statin therapy interacts with cytomegalovirus seropositivity and high C-reactive protein in reducing mortality among patients with angiographically significant coronary disease.},
  author={Benjamin D. Horne and Joseph Brent Muhlestein and John F. Carlquist and Tami L. Bair and Troy E. Madsen and Noal I Hart and Jeffrey L Anderson},
  journal={Circulation},
  year={2003},
  volume={107 2},
  pages={258-63}
}
BACKGROUND Seropositivity to cytomegalovirus (CMV) and elevated C-reactive protein (CRP) may jointly predict increased mortality rates in patients with coronary artery disease (CAD). Therapy with statins reduces lipid levels but may also have other beneficial (eg, antiinflammatory) effects. This study prospectively evaluated the effect of statins on CMV-and CRP-associated death among patients with significant, angiographically defined CAD. METHODS AND RESULTS We monitored 2315 patients with… CONTINUE READING

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