Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells.

@article{Walter2002StatinTA,
  title={Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells.},
  author={Dirk Walter and Kilian Rittig and Ferdinand Hermann Bahlmann and Rudolf Kirchmair and Marian Silver and Toshinori Murayama and Hiromi Nishimura and Douglas W. Losordo and Takayuki Asahara and Richard C. Cabot},
  journal={Circulation},
  year={2002},
  volume={105 25},
  pages={
          3017-24
        }
}
BACKGROUND Primary and secondary prevention trials suggest that statins possess favorable effects independent of cholesterol reduction. We investigated whether statin therapy may also accelerate reendothelialization after carotid balloon injury. METHODS AND RESULTS Simvastatin treatment in 34 male Sprague-Dawley rats accelerated reendothelialization of the balloon-injured arterial segments (reendothelialized area at 2 weeks, 12.3+/-1.8 versus 5.4+/-1.1 mm2, P< 0.01) and resulted in a dose… CONTINUE READING

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References

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Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2000