Statin reverses reduction of adiponectin receptor expression in infarcted heart and in TNF-alpha-treated cardiomyocytes in association with improved glucose uptake.

@article{Saito2007StatinRR,
  title={Statin reverses reduction of adiponectin receptor expression in infarcted heart and in TNF-alpha-treated cardiomyocytes in association with improved glucose uptake.},
  author={Yukio Saito and Daisuke Fujioka and Ken-ichi Kawabata and Tsuyoshi Kobayashi and Toshiaki Yano and Takamitsu Nakamura and Yasushi Kodama and H. Takano and Yoshinobu Kitta and Jyun-ei Obata and Kiyotaka Kugiyama},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={293 6},
  pages={H3490-7}
}
Statin treatment improves insulin resistance in skeletal muscle. Thus this study assessed whether statin may affect the myocardial expression levels of AdipoR1 and AdipoR2, receptors of adiponectin that enhance insulin sensitivity, and whether statin may improve insulin resistance in cardiomyocytes. Myocardial infarction (MI) was created by the ligation of the left coronary artery in male mice. Expression levels of mRNA and protein levels of AdipoR1 but not of AdipoR2 were significantly… CONTINUE READING

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