Statin myotoxicity: a review of genetic susceptibility factors.

@article{Needham2014StatinMA,
  title={Statin myotoxicity: a review of genetic susceptibility factors.},
  author={Merrilee Needham and Francis L Mastaglia},
  journal={Neuromuscular disorders : NMD},
  year={2014},
  volume={24 1},
  pages={4-15}
}
The 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA) reductase inhibitors (statins) are among the most common medications prescribed worldwide, but their efficacy and toxicity vary between individuals. One of the major factors contributing to intolerance and non-compliance are the muscle side-effects, which range from mild myalgia through to severe life-threatening rhabdomyolysis. One way to address this is pharmacogenomic screening, which aims to individualize therapy to maximize efficacy whilst… CONTINUE READING
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