Statin mediated protection of the ischemic myocardium.

  title={Statin mediated protection of the ischemic myocardium.},
  author={Douglas G. Wright and David Joseph Lefer},
  journal={Vascular pharmacology},
  volume={42 5-6},
Hypercholesterolemia is a major risk factor in the development of cardiovascular disease and HMG-CoA reductase inhibitors (i.e. statins) were originally designed to reduce serum cholesterol levels and thus reduce this risk factor. However, it has become increasingly apparent that the effects of statins extend well beyond their lipid lowering actions, and these pleiotropic effects have a major role in protecting the myocardium against ischemic injury. There have been a large number of clinical… CONTINUE READING
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