Statin inhibits leukocyte-endothelial interaction and prevents neuronal death induced by ischemia-reperfusion injury in the rat retina.

@article{Honjo2002StatinIL,
  title={Statin inhibits leukocyte-endothelial interaction and prevents neuronal death induced by ischemia-reperfusion injury in the rat retina.},
  author={Megumi Honjo and Hidenobu Tanihara and Kazuaki Nishijima and Junichi Kiryu and Y. Hasegawa Honda and Beatrice Y. J. T. Yue and Tatsuya Sawamura},
  journal={Archives of ophthalmology},
  year={2002},
  volume={120 12},
  pages={1707-13}
}
BACKGROUND Retinal ishchemia-induced neuronal death is believed to be a direct causal process in the development of many ocular diseases. The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, statin, is known to improve endothelial function in proinflammatory conditions. OBJECTIVE To investigate the effects of statin on leukocyte accumulation during ischemia-reperfusion injury and on subsequent retinal damage. METHODS Transient retinal ischemia was induced in Long-Evans rats for 60… CONTINUE READING
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