Statin inhibition of HMG-CoA reductase: a 3-dimensional view.

@article{Istvan2003StatinIO,
  title={Statin inhibition of HMG-CoA reductase: a 3-dimensional view.},
  author={Eva S Istvan},
  journal={Atherosclerosis. Supplements},
  year={2003},
  volume={4 1},
  pages={3-8}
}
Statins act by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and thereby reducing cholesterol synthesis. In X-ray crystallographic studies, we have determined the structures of the catalytic portions of the enzyme in complex with statin molecules. These studies show that the HMG-like moiety of statin molecules occupy the HMG binding site of the enzyme, with the hydrophobic groups of the statins occupying a binding site exposed by movement of flexible helices in the enzyme… CONTINUE READING