Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect.

@article{Cao2009StatininducedMD,
  title={Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect.},
  author={Peirang Cao and Jun-ichi Hanai and Preeti Tanksale and Shintaro Imamura and Vikas P Sukhatme and Stewart H. Lecker},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2009},
  volume={23 9},
  pages={2844-54}
}
Statins are widely used to treat hypercholesterolemia but can lead to a number of side effects in muscle, including rhabdomyolysis. Our recent findings implicated the induction of atrogin-1, a gene required for the development of muscle atrophy, in statin-induced muscle damage. Since statins inhibit many biochemical reactions besides cholesterol synthesis, we sought to define the statin-inhibited pathways responsible for atrogin-1 expression and muscle damage. We report here that lovastatin… CONTINUE READING
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