Statin-induced cholesterol lowering and plaque regression after 6 months of magnetic resonance imaging-monitored therapy.

@article{Lima2004StatininducedCL,
  title={Statin-induced cholesterol lowering and plaque regression after 6 months of magnetic resonance imaging-monitored therapy.},
  author={Jo{\~a}o A. C. Lima and Milind Y Desai and Henning Steen and William P Warren and Sandeep Gautam and Shenghan Lai},
  journal={Circulation},
  year={2004},
  volume={110 16},
  pages={2336-41}
}
BACKGROUND Statin therapy reduces adverse outcomes, with a minimal decrease in vessel stenosis. Magnetic resonance imaging (MRI) noninvasively detects atherosclerotic plaque (AP) reduction. We hypothesized that statin-induced AP regression can be monitored by MRI and detected earlier than previously reported and is significantly associated with its lipid-lowering effect. METHODS AND RESULTS APs in thoracic aorta were measured by combined surface/transesophageal MRI in 27 patients (treated… CONTINUE READING

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