Statin-induced blockade of prenylation alters nucleocytoplasmic shuttling of GTP-binding proteins gamma2 and beta2 and enhances their suppressive effect on glucocorticoid receptor transcriptional activity.

@article{Kino2005StatininducedBO,
  title={Statin-induced blockade of prenylation alters nucleocytoplasmic shuttling of GTP-binding proteins gamma2 and beta2 and enhances their suppressive effect on glucocorticoid receptor transcriptional activity.},
  author={Tomoshige Kino and Tohru Kozasa and George P. Chrousos},
  journal={European journal of clinical investigation},
  year={2005},
  volume={35 8},
  pages={
          508-13
        }
}
BACKGROUND We previously reported that the guanine tri-phosphate-binding proteins (G) beta and gamma are both localized in the nucleus, in addition to their expected cytoplasmic/plasma membrane localization. These proteins, as a heterodimeric complex, suppress glucocorticoid response element-mediated transcriptional activity of the glucocorticoid receptor through direct physical interactions between Gbeta and the glucocorticoid receptor. MATERIALS AND METHODS As Ggamma is prenylated at a… CONTINUE READING

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