Statin-induced apoptosis and skeletal myopathy.

@article{Dirks2006StatininducedAA,
  title={Statin-induced apoptosis and skeletal myopathy.},
  author={Amie J. Dirks and Kimberly Marie Jones},
  journal={American journal of physiology. Cell physiology},
  year={2006},
  volume={291 6},
  pages={
          C1208-12
        }
}
  • A. Dirks, K. Jones
  • Published 1 December 2006
  • Medicine
  • American journal of physiology. Cell physiology
Over 100 million prescriptions were filled for statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) in 2004. Statins were originally developed to lower plasma cholesterol in patients with hypercholesterolemia and are the most effective drugs on the market in doing so. Because of the discovered pleiotropic effects of statins, the use has expanded to the treatment of many other conditions, including ventricular arrythmias, idiopathic dilated cardiomyopathy, cancer, osteoporosis… 
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Statin-induced myopathies.
Mechanism of statin-induced rhabdomyolysis.
TLDR
The findings that statins induce depletion of isoprenoids and inactivation of small GTPases, especially Rab, which are critical for statin-induced myotoxicity may contribute to the prevention and treatment of statin' adverse effects on skeletal muscle and development of safer anti-hypercholesterolemia drugs.
Statin myopathy: Incidence, risk factors, and pathophysiology
TLDR
The development of a standardized system for description and documentation of statin-associated myopathy that includes the entire spectrum of muscle complaints would provide valuable data for researchers and clinicians seeking to better understandstatin-induced muscle complaints.
Fluvastatin-induced alterations of skeletal muscle function in hypercholesterolaemic rats
TLDR
Results clearly indicate that statin administration in these animals results in a myopathy characterized by decreased muscle force and elevated plasma CK level.
Statin‐associated myopathy and its exacerbation with exercise
TLDR
An overview of research that specifically addresses the combination of statin‐associated myopathy and physical activity is provided and some deficiencies in the available literature are highlighted, as well as future directions for this important subset ofstatin‐ associated myopathy are highlighted.
The broad spectrum of statin myopathy: from myalgia to rhabdomyolysis
TLDR
It is important to maintain perspective by looking at the impact of statin myopathy relative to the impactOf preventing atherosclerotic complications, the potential benefits of therapy must outweigh the risks and the benefit/risk ratio is overwhelmingly positive.
Statin-induced Myopathy in Skeletal Muscle: the Role of Exercise
  • H. Kwak
  • Biology
    Journal of lifestyle medicine
  • 2014
TLDR
This review will briefly provide a comprehensive summary regarding the effects of statins on skeletal myopathy, and discuss the potential mechanisms ofstatin-induced myopathy and the role of exercise in statin- induced myopathy in skeletal muscle.
A Neuromuscular Approach to Statin-Related Myotoxicity
  • S. Baker, I. Samjoo
  • Medicine, Biology
    Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
  • 2008
TLDR
A clinical management algorithm is presented which outlines a variety of co-morbidities which can potentiate the adverse effects of statins on muscle and a rational approach to the selection of those patients most likely to benefit from skeletal muscle biopsy is discussed.
Mechanisms of statin-associated skeletal muscle-associated symptoms.
The Impact of Exercise on Statin-Associated Skeletal Muscle Myopathy
TLDR
The results from this study suggest that exercise (Nov, Acct) does not exacerbate statin-induced myopathy in ApoE-/- mice, yet statin treatment reduces activity in a manner that prevents muscle from mounting a beneficial adaptive response to training.
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