Statin drug interactions and related adverse reactions

@article{Bellosta2012StatinDI,
  title={Statin drug interactions and related adverse reactions},
  author={Stefano Bellosta and Alberto Corsini},
  journal={Expert Opinion on Drug Safety},
  year={2012},
  volume={11},
  pages={933 - 946}
}
Introduction: Statin monotherapy is generally well tolerated, with a low frequency of adverse events. The most important adverse effects associated with statins are myopathy and an asymptomatic increase in hepatic transaminases, both of which occur infrequently. Because statins are prescribed on a long-term basis, their possible interactions with other drugs deserve particular attention, as many patients will typically receive pharmacological therapy for concomitant conditions during the course… 
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References

SHOWING 1-10 OF 117 REFERENCES
Simvastatin interactions with other drugs
TLDR
The interactions between simvastatin and other drugs and the latest FDA recommendations regarding the safe use of this statin are presented and Physicians need to adjust the recent recommendations made by the FDA in clinical practice in order to prevent treatment complications.
Safety of Statins: Focus on Clinical Pharmacokinetics and Drug Interactions
TLDR
This review summarizes the pharmacokinetic properties of statins and emphasizes their clinically relevant drug interactions, as many patients will typically receive pharmacological therapy for concomitant conditions during the course of statin treatment.
Drug–drug interaction with statins
TLDR
The most important adverse effects associated with statins are myopathy and an asymptomatic increase in hepatic transaminases, both of which occur infrequently.
Drug–drug interactions with statins: will pitavastatin overcome the statins’ Achilles’ heel?
TLDR
The addition of pitavastatin to the range of available statins provides prescribing physicians with a new treatment option that is expected to have a low risk of DDIs and related ADRs, and should help physicians individualise lipid-lowering regimens based on the patient profile and concomitant medications.
Rosuvastatin-Associated Adverse Effects and Drug-Drug Interactions in the Clinical Setting of Dyslipidemia
TLDR
Evidence with regard to the safety and interactions of rosuvastatin is reviewed, which appears to be relatively safe and well tolerated, sharing the adverse effects that are considered class effects of statins.
Statin safety and drug interactions: clinical implications.
  • M. Bottorff
  • Medicine, Biology
    The American journal of cardiology
  • 2006
The potential for drug interactions with statin therapy in Ireland
TLDR
Investigation of co-prescribing of the frequently-used statin medications with interacting drugs found that pravastatin, which does not undergo significant hepatic metabolism, is the statin of choice.
Clopidogrel-drug interactions.
Pharmacogenomics and adverse drug reactions: the case of statins
TLDR
Despite there being a statin–gene association for myopathy, in the case of some statins the usefulness of this information still needs to be proven and the methodological issues involved in the establishment of such an association are explored.
Statin-induced myopathies.
...
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