Statin drug interactions and related adverse reactions

@article{Bellosta2012StatinDI,
  title={Statin drug interactions and related adverse reactions},
  author={Stefano Bellosta and Alberto Corsini},
  journal={Expert Opinion on Drug Safety},
  year={2012},
  volume={11},
  pages={933 - 946}
}
Introduction: Statin monotherapy is generally well tolerated, with a low frequency of adverse events. The most important adverse effects associated with statins are myopathy and an asymptomatic increase in hepatic transaminases, both of which occur infrequently. Because statins are prescribed on a long-term basis, their possible interactions with other drugs deserve particular attention, as many patients will typically receive pharmacological therapy for concomitant conditions during the course… 
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Statin drug interactions and related adverse reactions: an update
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A better understanding of the incidence and clinical significance of statin DDIs will help physicians in fine-tuning the lipid-lowering therapeutic interventions thus providing their patients with an evidence-based, safe and cost-effective clinical support.
A Brief Drug Class Review: Considerations for Statin Use, Toxicity, and Drug Interactions
  • J. Wooten
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    Southern medical journal
  • 2018
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P Practitioners who care for patients receiving statins should understand the pharmacologic differences among these drugs, as well as the varied drug interaction potential that all statins possess.
Selective serotonin reuptake inhibitor drug interactions in patients receiving statins.
  • C. Andrade
  • Medicine, Biology
    The Journal of clinical psychiatry
  • 2014
TLDR
Elderly patients commonly receive statin drugs for the primary or secondary prevention of cardiovascular and cerebrovascular events and SSRIs for the treatment of depression, anxiety, or other conditions, and a detailed literature review of statin metabolism and of SSRI effects on CYP enzymes suggests that escitalopram, citaloprams, and paroxetine are almost certain to be safe with all statins.
Potential statin-drug interactions: prevalence and clinical significance
TLDR
Although they do not differ between outpatient and inpatient settings, new hazardous coprescriptions are more frequently generated in hospital, and Caution is required when acenocoumarol is coprescribed with statins, especially simvastatin.
Potential statin drug interactions in elderly patients: a review
TLDR
A better and more close attention to the potential DDIs among statins and other therapeutic options will help physicians in selecting the more effective and less harmful treatment for their patients.
Drug Interactions
Drug–Drug Interactions Between HMG-CoA Reductase Inhibitors (Statins) and Antiviral Protease Inhibitors
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Simvastatin and lovastatin have the highest potency for drug–drug interaction with potent CYP3A inhibitors such as ritonavir- or cobicistat-boosted HIV-PI or the hepatitis C virus, telaprevir or boceprevir, and therefore their coadministration is contraindicated.
Safety and efficacy of statin therapy
TLDR
Although hepatotoxicity has been a previous concern when using statin therapy, data suggest that statins are safe and that levels of liver enzymes do not need to be checked routinely and data from trials on PCSK9 inhibitors suggest that low LDL-cholesterol levels are safe.
Statin-induced liver and muscle toxicities
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The mechanisms of statin-drug interactions and their adverse effects are reviewed with a particular focus on SILT and SIMT, with an increasing concern currently about their safety associated with genetic polymorphisms.
Life‐threatening drug interactions: what the physician needs to know
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Focusing on those drug–drug interactions that are clinically relevant is necessary, and increasingly, tools and reliable sources of this information are easily accessible.
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