Statin drug interactions and related adverse reactions

  title={Statin drug interactions and related adverse reactions},
  author={Stefano Bellosta and Alberto Corsini},
  journal={Expert Opinion on Drug Safety},
  pages={933 - 946}
Introduction: Statin monotherapy is generally well tolerated, with a low frequency of adverse events. The most important adverse effects associated with statins are myopathy and an asymptomatic increase in hepatic transaminases, both of which occur infrequently. Because statins are prescribed on a long-term basis, their possible interactions with other drugs deserve particular attention, as many patients will typically receive pharmacological therapy for concomitant conditions during the course… 
Statin drug interactions and related adverse reactions: an update
A better understanding of the incidence and clinical significance of statin DDIs will help physicians in fine-tuning the lipid-lowering therapeutic interventions thus providing their patients with an evidence-based, safe and cost-effective clinical support.
A Brief Drug Class Review: Considerations for Statin Use, Toxicity, and Drug Interactions
  • J. Wooten
  • Medicine, Biology
    Southern medical journal
  • 2018
P Practitioners who care for patients receiving statins should understand the pharmacologic differences among these drugs, as well as the varied drug interaction potential that all statins possess.
Selective serotonin reuptake inhibitor drug interactions in patients receiving statins.
  • C. Andrade
  • Medicine, Biology
    The Journal of clinical psychiatry
  • 2014
Elderly patients commonly receive statin drugs for the primary or secondary prevention of cardiovascular and cerebrovascular events and SSRIs for the treatment of depression, anxiety, or other conditions, and a detailed literature review of statin metabolism and of SSRI effects on CYP enzymes suggests that escitalopram, citaloprams, and paroxetine are almost certain to be safe with all statins.
Potential statin-drug interactions: prevalence and clinical significance
Although they do not differ between outpatient and inpatient settings, new hazardous coprescriptions are more frequently generated in hospital, and Caution is required when acenocoumarol is coprescribed with statins, especially simvastatin.
Potential statin drug interactions in elderly patients: a review
A better and more close attention to the potential DDIs among statins and other therapeutic options will help physicians in selecting the more effective and less harmful treatment for their patients.
Drug Interactions
Drug–Drug Interactions Between HMG-CoA Reductase Inhibitors (Statins) and Antiviral Protease Inhibitors
Simvastatin and lovastatin have the highest potency for drug–drug interaction with potent CYP3A inhibitors such as ritonavir- or cobicistat-boosted HIV-PI or the hepatitis C virus, telaprevir or boceprevir, and therefore their coadministration is contraindicated.
Safety and efficacy of statin therapy
Although hepatotoxicity has been a previous concern when using statin therapy, data suggest that statins are safe and that levels of liver enzymes do not need to be checked routinely and data from trials on PCSK9 inhibitors suggest that low LDL-cholesterol levels are safe.
Statin-induced liver and muscle toxicities
The mechanisms of statin-drug interactions and their adverse effects are reviewed with a particular focus on SILT and SIMT, with an increasing concern currently about their safety associated with genetic polymorphisms.
Life‐threatening drug interactions: what the physician needs to know
Focusing on those drug–drug interactions that are clinically relevant is necessary, and increasingly, tools and reliable sources of this information are easily accessible.


Safety of Statins: Focus on Clinical Pharmacokinetics and Drug Interactions
This review summarizes the pharmacokinetic properties of statins and emphasizes their clinically relevant drug interactions, as many patients will typically receive pharmacological therapy for concomitant conditions during the course of statin treatment.
Simvastatin interactions with other drugs
The interactions between simvastatin and other drugs and the latest FDA recommendations regarding the safe use of this statin are presented and Physicians need to adjust the recent recommendations made by the FDA in clinical practice in order to prevent treatment complications.
Drug–drug interaction with statins
The most important adverse effects associated with statins are myopathy and an asymptomatic increase in hepatic transaminases, both of which occur infrequently.
Drug–drug interactions with statins: will pitavastatin overcome the statins’ Achilles’ heel?
The addition of pitavastatin to the range of available statins provides prescribing physicians with a new treatment option that is expected to have a low risk of DDIs and related ADRs, and should help physicians individualise lipid-lowering regimens based on the patient profile and concomitant medications.
Rosuvastatin-Associated Adverse Effects and Drug-Drug Interactions in the Clinical Setting of Dyslipidemia
Evidence with regard to the safety and interactions of rosuvastatin is reviewed, which appears to be relatively safe and well tolerated, sharing the adverse effects that are considered class effects of statins.
Statin safety and drug interactions: clinical implications.
  • M. Bottorff
  • Medicine, Biology
    The American journal of cardiology
  • 2006
The potential for drug interactions with statin therapy in Ireland
Investigation of co-prescribing of the frequently-used statin medications with interacting drugs found that pravastatin, which does not undergo significant hepatic metabolism, is the statin of choice.
Clopidogrel-drug interactions.
Pharmacogenomics and adverse drug reactions: the case of statins
Despite there being a statin–gene association for myopathy, in the case of some statins the usefulness of this information still needs to be proven and the methodological issues involved in the establishment of such an association are explored.
Statin-induced myopathies.