Statin attenuates high glucose-induced and angiotensin II-induced MAP kinase activity through inhibition of NAD(P)H oxidase activity in cultured mesangial cells.

@article{Yu2005StatinAH,
  title={Statin attenuates high glucose-induced and angiotensin II-induced MAP kinase activity through inhibition of NAD(P)H oxidase activity in cultured mesangial cells.},
  author={Hongwen Yu and Toyoshi Inoguchi and Masaharu Nakayama and Hirohito Tsubouchi and Nobuhiro Sato and Noriyuki Sonoda and Shuji Sasaki and Kazuto Kobayashi and Hajime Nawata},
  journal={Medicinal chemistry (Shariqah (United Arab Emirates))},
  year={2005},
  volume={1 5},
  pages={461-6}
}
An increased oxidative stress may contribute to the development of diabetic nephropathy. We have recently reported that high glucose level stimulated superoxide production through protein kinase C (PKC)-dependent activation of NAD(P)H oxidase in cultured vascular cells. Here we show that 3-hydroxy-3-methylglutaryl CoA reductase inhibitor (statin) attenuates both high glucose level-induced and angiotensin II (Ang II)-induced activation of p42/44 mitogen-activated kinase (MAP kinase) in cultured… CONTINUE READING