Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management

@article{Stroes2015StatinassociatedMS,
  title={Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management},
  author={Erik S. G. Stroes and Paul D. Thompson and Alberto Corsini and Georgirene D. Vladutiu and Frederick J. Raal and Kausik K. Ray and Michael Roden and Evan A. Stein and Lale S Tokg{\"o}zoğlu and B{\o}rge Gr{\o}nne Nordestgaard and Eric Bruckert and Guy G. De Backer and Ronald M. Krauss and Ulrich Laufs and Raul Dias Santos and Robert A. Hegele and G. Kees Hovingh and Lawrence A Leiter and François Mach and Winfried M{\"a}rz and Connie B. Newman and Olov Wiklund and Terry A. Jacobson and Alberico Luigi Catapano and M. John Chapman and Henry N. Ginsberg and Erik S. G. Stroes and Paul D. Thompson and Alberto Corsini and Georgirene D. Vladutiu and Frederick J. Raal and Kausik K. Ray and Michael Roden and Evan A. Stein and Lale S Tokg{\"o}zoğlu and B{\o}rge Gr{\o}nne Nordestgaard and Eric Bruckert and Ronald M. Krauss and Ulrich Laufs and Raul Dias Santos and Winfried M{\"a}rz and Connie B. Newman and M. John Chapman and Henry N. Ginsberg and Guy G. De Backer and Alberico Luigi Catapano and Robert A. Hegele and G. Kees Hovingh and Terry A. Jacobson and Lawrence A Leiter and François Mach and Olov Wiklund},
  journal={European Heart Journal},
  year={2015},
  volume={36},
  pages={1012 - 1022}
}
Statin-associated muscle symptoms (SAMS) are one of the principal reasons for statin non-adherence and/or discontinuation, contributing to adverse cardiovascular outcomes. This European Atherosclerosis Society (EAS) Consensus Panel overviews current understanding of the pathophysiology of statin-associated myopathy, and provides guidance for diagnosis and management of SAMS. Statin-associated myopathy, with significant elevation of serum creatine kinase (CK), is a rare but serious side effect… 

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References

SHOWING 1-10 OF 170 REFERENCES

Statin intolerance.

  • Z. Ahmad
  • Medicine, Biology
    The American journal of cardiology
  • 2014

Diagnosis, prevention, and management of statin adverse effects and intolerance: Canadian Working Group Consensus update.

Statin-Associated Myopathy with Normal Creatine Kinase Levels

It appears that muscle symptoms of some patients receiving statin therapy might represent a muscle toxicity below the threshold needed to increase creatine kinase levels, which could rule out statin-associated myopathy in patients with muscle symptoms.

Mild to Moderate Muscular Symptoms with High-Dosage Statin Therapy in Hyperlipidemic Patients —The PRIMO Study

It is demonstrated that mild to moderate muscular symptoms with high-dosage statin therapy may be more common and exert a greater impact on everyday lives than previously thought.

The safety of statins in clinical practice

Risks Associated with Statin Therapy: A Systematic Overview of Randomized Clinical Trials: P113

Background— Although statins reduce the risk of cardiovascular events, concerns about adverse effects may deter physicians from prescribing these agents. We performed a systematic overview of

Prevalence and risk factors of muscle complications secondary to statins

Older age, longer duration of statin use, diabetes, stroke, and lower body mass index were associated with increased risk of developing muscle complications and adverse reactions to statins may be more common than previously reported.

Narrative Review: Statin-Related Myopathy

The pathophysiology, epidemiology, clinical features, and management of statin-related myopathy are reviewed because even a small percentage of tens of millions of patients is a large number, and statin myopathy can adversely affect both quality of life and adherence to this potentially life-saving treatment.
...