Static compression of articular cartilage can reduce solute diffusivity and partitioning: implications for the chondrocyte biological response.

@article{Quinn2001StaticCO,
  title={Static compression of articular cartilage can reduce solute diffusivity and partitioning: implications for the chondrocyte biological response.},
  author={T M Khayat Quinn and V{\'e}ronique Morel and J-J. Meister},
  journal={Journal of biomechanics},
  year={2001},
  volume={34 11},
  pages={1463-9}
}
Chondrocytes depend upon solute transport within the avascular extracellular matrix of adult articular cartilage for many of their biological activities. Alterations to bioactive solute transport may, therefore, represent a mechanism by which cartilage compression is transduced into cellular metabolic responses. We investigated the effects of cartilage static compression on diffusivity and partitioning of a range of model solutes including dextrans of molecular weights 3 and 40 kDa, and… CONTINUE READING