Static and dynamic properties of phospholipid bilayer nanodiscs.

  title={Static and dynamic properties of phospholipid bilayer nanodiscs.},
  author={Minoru Nakano and Masakazu Fukuda and Takayuki Kudo and Masakazu Miyazaki and Yusuke Wada and Naoya Matsuzaki and Hitoshi Endo and Tetsurou Handa},
  journal={Journal of the American Chemical Society},
  volume={131 23},
Nanodiscs are phospholipid-protein complexes which are relevant to nascent high-density lipoprotein and are applicable as a drug carrier and a tool to immobilize membrane proteins. We evaluated the structure and dynamics of the nanoparticles consisting of dimyristoylphosphatidylcholine (DMPC) and apolipoprotein A-I (apoA-I) with small-angle neutron scattering (SANS) and fluorescence methods and compared them with static/dynamic properties for large unilamellar vesicles. SANS revealed that the… CONTINUE READING
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