Static and cyclic mechanical loading of mesenchymal stem cells on elastomeric, electrospun polyurethane meshes.

@article{Cardwell2015StaticAC,
  title={Static and cyclic mechanical loading of mesenchymal stem cells on elastomeric, electrospun polyurethane meshes.},
  author={R. D. Cardwell Dr. Robert D. Cardwell and Jonathan A. Kluge and Patrick Scott Thayer and Scott A Guelcher and Linda A Dahlgren and David L Kaplan and Aaron S. Goldstein},
  journal={Journal of biomechanical engineering},
  year={2015},
  volume={137 7}
}
Biomaterial substrates composed of semi-aligned electrospun fibers are attractive supports for the regeneration of connective tissues because the fibers are durable under cyclic tensile loads and can guide cell adhesion, orientation, and gene expression. Previous studies on supported electrospun substrates have shown that both fiber diameter and mechanical deformation can independently influence cell morphology and gene expression. However, no studies have examined the effect of mechanical… CONTINUE READING
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