Static and Evolving Norovirus Genotypes: Implications for Epidemiology and Immunity

@inproceedings{Parra2017StaticAE,
  title={Static and Evolving Norovirus Genotypes: Implications for Epidemiology and Immunity},
  author={Gabriel I Parra and R. Burke Squires and Consolee K Karangwa and Jordan A Johnson and Cara J Lepore and Stanislav V. Sosnovtsev and Kim Y Green},
  booktitle={PLoS pathogens},
  year={2017}
}
Noroviruses are major pathogens associated with acute gastroenteritis worldwide. Their RNA genomes are diverse, with two major genogroups (GI and GII) comprised of at least 28 genotypes associated with human disease. To elucidate mechanisms underlying norovirus diversity and evolution, we used a large-scale genomics approach to analyze human norovirus sequences. Comparison of over 2000 nearly full-length ORF2 sequences representing most of the known GI and GII genotypes infecting humans showed… CONTINUE READING
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