Stathmin: a tubulin-sequestering protein which forms a ternary T2S complex with two tubulin molecules.

@article{Jourdain1997StathminAT,
  title={Stathmin: a tubulin-sequestering protein which forms a ternary T2S complex with two tubulin molecules.},
  author={L Jourdain and Patrick A. Curmi and Andr{\'e} Sobel and Dominique Pantaloni and M F Carlier},
  journal={Biochemistry},
  year={1997},
  volume={36 36},
  pages={10817-21}
}
Stathmin is an important regulatory protein thought to control the dynamics of microtubules through the cell cycle in a phosphorylation-dependent manner. Here we show that stathmin interacts with two molecules of dimeric alphabeta-tubulin to form a tight ternary T2S complex, sedimenting at 7.7 S. This complex appears in slow association-dissociation equilibrium in the analytical ultracentrifuge. The T2S complex is formed under a variety of ionic conditions, either from GTP- or GDP-tubulin or… CONTINUE READING

From This Paper

Topics from this paper.
96 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 96 extracted citations

Similar Papers

Loading similar papers…