State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.

@article{Sheng2015StateoftheartSF,
  title={State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.},
  author={Chunquan Sheng and Guoqiang Dong and Zhenyuan Miao and Wannian Zhang and Wei Wang},
  journal={Chemical Society reviews},
  year={2015},
  volume={44 22},
  pages={8238-59}
}
Targeting protein-protein interactions (PPIs) has emerged as a viable approach in modern drug discovery. However, the identification of small molecules enabling us to effectively interrupt their interactions presents significant challenges. In the recent past, significant advances have been made in the development of new biological and chemical strategies… CONTINUE READING
  • Blog articles referencing this paper

    • Review of 2015 reviews

      Practical Fragments · Dec 30, 2015

    • Don't see an article that should be here?

  • Presentations referencing similar topics