State of sulfhydryl in selenite cataract.

  title={State of sulfhydryl in selenite cataract.},
  author={Larry L. David and Thomas R. Shearer},
  journal={Toxicology and applied pharmacology},
  volume={74 1},
A dose of 20 mumol selenite/kg body weight is a potent and a very rapid inducer of cataracts in young rats. We investigated the rate at which physiological concentrations of selenite would catalyze the oxidation of glutathione in vitro and found that selenite was a strong sulfhydryl oxidant. To test if selenite had the same effect in vivo, the oxidation state of five kinds of lenticular sulfur were measured in suckling rats following a cataractous dose of selenite. The measurements included… CONTINUE READING