The article covers results of studies concerning psychologic and clinical neurologic state of Temirtau inhabitants. Early clinical forms of cerebro-vascular diseases were more frequent among males, but cryptogenic encephalopathies were more prevalent among females. Among the males examined, the early clinical signs of cerebro-vascular diseases were seen in all age groups, more often at the age of 20-29. Among the females, cryptogenic encephalopathies were more often at the age over 40. Early clinical forms of cerebro-vascular diseases and cryptogenic encephalopathies were associated with asthenic, astheno-hypochondriac, astheno-depressive syndrome and vegetative dysfunction syndrome. The group with early clinical signs of cerebro-vascular diseases was characterized by prevalent asthenic syndrome, but the cryptogenic encephalopathy group had more often astheno-hypochondriac syndrome.