State of art and recent developments of anti-cancer strategies based on TRAIL.

@article{Bernardi2012StateOA,
  title={State of art and recent developments of anti-cancer strategies based on TRAIL.},
  author={Stella Bernardi and Paola Secchiero and Giorgio Zauli},
  journal={Recent patents on anti-cancer drug discovery},
  year={2012},
  volume={7 2},
  pages={
          207-17
        }
}
Multicellular organisms require apoptosis whereby the human body eliminates unnecessary and/or damaged cells. Apoptosis, or programmed cell death, can indeed be considered as a constitutive anti-cancer mechanism that seems to be defective in more than 50% of cancers. Molecular insights on the biology of the apoptotic process have led to the development of new anti-cancer strategies aiming at recovering and stimulating this process. Preclinical and clinical studies of our and other groups have… CONTINUE READING
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