State of aggregation

  • Published 2011 in Nature Neuroscience


in vitro. They reported that these synthetic Aβ oligomers, but not fibrils or monomeric Aβ1–42, impaired long-term potentiation in Prnp−/− mouse hippocampal slices. A different group, however, failed to replicate the long-term potentiation impairment when using virus-mediated overexpression of the C-terminal fragment of APP in organotypic brain slices (the… (More)
DOI: 10.1038/nn0411-399