State-dependent nickel block of a high-voltage-activated neuronal calcium channel.

@article{McFarlane1998StatedependentNB,
  title={State-dependent nickel block of a high-voltage-activated neuronal calcium channel.},
  author={Morag McFarlane and William F. Gilly},
  journal={Journal of neurophysiology},
  year={1998},
  volume={80 4},
  pages={1678-85}
}
Effect of nickel ions (Ni2+) on noninactivating calcium channels in squid giant fiber lobe (GFL) neurons were investigated with whole cell voltage clamp. Three different effects of Ni2+ were observed to be associated with distinct Ca2+ channel activation states. 1) Nickel ions appear to stabilize closed channel states and, as a result, slow activation kinetics. 2) Nickel ions block open channels with little voltage dependence over a wide range of potentials. 3) Block of open channels by Ni2… CONTINUE READING

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