State-dependent modification of ATP-sensitive K+ channels by phosphatidylinositol 4,5-bisphosphate.

@article{Okamura2001StatedependentMO,
  title={State-dependent modification of ATP-sensitive K+ channels by phosphatidylinositol 4,5-bisphosphate.},
  author={Mayumi Okamura and Masafumi Kakei and Kotaro Ichinari and Akihiro Miyamura and Naoya Oketani and Nobuyuki Koriyama and Chuwa Tei},
  journal={American journal of physiology. Cell physiology},
  year={2001},
  volume={280 2},
  pages={C303-8}
}
With inside-out patch recordings in ventricular myocytes from the hearts of guinea pigs, we studied ATP-sensitive K+ (K(ATP)) channels activated by phosphatidylinositol 4,5-bisphosphate (PIP2) with respect to sensitivity to ATP when in either a rundown state (RS) or a non-rundown state (NRS). Rundown of K(ATP) channels was induced by exposure either to ATP-free solution or to ATP-free solution containing 19 microM Ca2+. Exposure of membrane patches to 10 microM PIP2 reactivated channels with… CONTINUE READING