State-dependent impairment in object recognition after hippocampal NOS inhibition.

  title={State-dependent impairment in object recognition after hippocampal NOS inhibition.},
  author={Arjan Blokland and Jos Prickaerts and Wiel H H Honig and Jan de Vente},
  volume={9 18},
In the present study we investigated the consequences of hippocampal nitric oxide synthase (NOS) inhibition on the performance in an object recognition task in rats. In a first study we injected Nomega-nitro-L-arginine (L-NA) into the hippocampus directly after the first trial. One hour later the discrimination performance of the animals was assessed. It was found that 10 microg and 30 microg, but not 3 microg, L-NA impaired the performance of the rats. In a second study in which we injected L… CONTINUE READING

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