State-dependent cross-inhibition between transmitter-gated cation channels

  title={State-dependent cross-inhibition between transmitter-gated cation channels},
  author={Baljit S. Khakh and Xiaoping Zhou and Jason Sydes and James J Galligan and Henry A. Lester},
Transmitter-gated cation channels are detectors of excitatory chemical signals at synapses in the nervous system. Here we show that structurally distinct α3β4 nicotinic and P2X2 channels influence each other when co-activated. The activation of one channel type affects distinct kinetic and conductance states of the other, and co-activation results in non-additive responses owing to inhibition of both channel types. State-dependent inhibition of nicotinic channels is revealed most clearly with… CONTINUE READING