State-Dependent Spike-Timing Relationships between Hippocampal and Prefrontal Circuits during Sleep

@article{Wierzynski2009StateDependentSR,
  title={State-Dependent Spike-Timing Relationships between Hippocampal and Prefrontal Circuits during Sleep},
  author={Casimir M. Wierzynski and Evgueniy V Lubenov and Ming Hong Gu and Athanassios G Siapas},
  journal={Neuron},
  year={2009},
  volume={61},
  pages={587-596}
}
Cortico-hippocampal interactions during sleep are believed to reorganize neural circuits in support of memory consolidation. However, spike-timing relationships across cortico-hippocampal networks-key determinants of synaptic changes-are poorly understood. Here we show that cells in prefrontal cortex fire consistently within 100 ms after hippocampal cells in naturally sleeping animals. This provides evidence at the single cell-pair level for highly consistent directional interactions between… CONTINUE READING
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