State-Dependent Modulation of Locomotion by GABAergic Spinal Sensory Neurons

@article{Fidelin2015StateDependentMO,
  title={State-Dependent Modulation of Locomotion by GABAergic Spinal Sensory Neurons},
  author={Kevin Fidelin and Lydia Djenoune and Caleb C. A. Stokes and Andrew E. Prendergast and Johanna Gomez and Audrey Baradel and Filippo Del Bene and Claire Wyart},
  journal={Current Biology},
  year={2015},
  volume={25},
  pages={3035-3047}
}
The cerebrospinal fluid (CSF) constitutes an interface through which chemical cues can reach and modulate the activity of neurons located at the epithelial boundary within the entire nervous system. Here, we investigate the role and functional connectivity of a class of GABAergic sensory neurons contacting the CSF in the vertebrate spinal cord and referred to as CSF-cNs. The remote activation of CSF-cNs was shown to trigger delayed slow locomotion in the zebrafish larva, suggesting that these… CONTINUE READING

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