State-Dependent Inactivation of the α1g T-Type Calcium Channel

  title={State-Dependent Inactivation of the α1g T-Type Calcium Channel},
  author={J. R. Serrano and Edward Perez-Reyes and Stephen W. Jones},
  journal={The Journal of General Physiology},
  pages={185 - 202}
We have examined the kinetics of whole-cell T-current in HEK 293 cells stably expressing the alpha1G channel, with symmetrical Na(+)(i) and Na(+)(o) and 2 mM Ca(2+)(o). After brief strong depolarization to activate the channels (2 ms at +60 mV; holding potential -100 mV), currents relaxed exponentially at all voltages. The time constant of the relaxation was exponentially voltage dependent from -120 to -70 mV (e-fold for 31 mV; tau = 2.5 ms at -100 mV), but tau = 12-17 ms from-40 to +60 mV… CONTINUE READING
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