Stat5a is mandatory for adult mammary gland development and lactogenesis.

  title={Stat5a is mandatory for adult mammary gland development and lactogenesis.},
  author={Xiong Liu and Gertraud W. Robinson and K U Wagner and Lisa A. Garrett and Anthony Wynshaw-Boris and Lothar Hennighausen},
  journal={Genes & development},
  volume={11 2},
Prolactin (PRL) induces mammary gland development (defined as mammopoiesis) and lactogenesis. Binding of PRL to its receptor leads to the phosphorylation and activation of STAT (signal transducers and activators of transcription) proteins, which in turn promote the expression of specific genes. The activity pattern of two STAT proteins, Stat5a and Stat5b, in mammary tissue during pregnancy suggests an active role for these transcription factors in epithelial cell differentiation and milk… CONTINUE READING
Highly Influential
This paper has highly influenced 28 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS