Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia

  title={Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia},
  author={Andrea Hoelbl and Christian Schuster and Boris Kovacic and Bingmei Zhu and Mark C Wickre and Maria A Hoelzl and Sabine Fajmann and Florian Grebien and Wolfgang Warsch and Gabriele Stengl and Lothar Hennighausen and Valeria Poli and Hartmut Beug and Richard Moriggl and Veronika Sexl},
  booktitle={EMBO molecular medicine},
Tumourigenesis caused by the Bcr/Abl oncoprotein is a multi-step process proceeding from initial to tumour-maintaining events and finally results in a complex tumour-supporting network. A key to successful cancer therapy is the identification of critical functional nodes in an oncogenic network required for disease maintenance. So far, the transcription factors Stat3 and Stat5a/b have been implicated in bcr/abl-induced initial transformation. However, to qualify as a potential drug target, a… CONTINUE READING

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