Stat5 expression is required for IgE-mediated mast cell function.

  title={Stat5 expression is required for IgE-mediated mast cell function.},
  author={Brian O. Barnstein and Geqiang Li and Zhengqi Wang and Sarah Kennedy and Charles H. Chalfant and Hiroshi Nakajima and Kevin D. Bunting and John Jake Ryan},
  journal={Journal of immunology},
  volume={177 5},
The mast cell (MC) inflammatory response is now linked not only to atopy, but also to arthritis, multiple sclerosis, heart disease, and resistance to bacterial infection. In the current study, we demonstrate that the signal transducer and activator of transcription 5 (Stat5) is rapidly activated by IgE cross-linkage, and that its expression is critical to the MC response. Stat5-deficient (Stat5KO) MC demonstrated a significant decrease in IgE-mediated degranulation, leukotriene B4 production… CONTINUE READING