Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells

@article{Tomida2007Stat3UE,
  title={Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells},
  author={Mikio Tomida and Hideki Ohtake and Takashi Yokota and Yasuhito Kobayashi and Masafumi Kurosumi},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2007},
  volume={134},
  pages={551-559}
}
To discover new molecular targets for cancer therapy and diagnosis, we surveyed signal transducers and activators of transcription 3 (Stat3)-regulated genes, because constitutive activation of Stat3 is associated with a wide variety of human malignancies. We investigated the Stat3-regulated genes in 293 cells with cDNA microarray analysis and found that Nicotinamide N-methyltransferase (NNMT) was induced on stimulation of the cells with leukemia inhibitory factor. We examined the expression of… CONTINUE READING
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