Stat3 promotes invasion of esophageal squamous cell carcinoma through up-regulation of MMP2

@article{Xuan2014Stat3PI,
  title={Stat3 promotes invasion of esophageal squamous cell carcinoma through up-regulation of MMP2},
  author={Xaioyan Xuan and Shanshan Li and Xi Zhong Lou and Xianzhao Zheng and Yunyun Li and Feng Wang and Yuan Gao and Hongyan Zhang and Hongliu He and Qingru Zeng},
  journal={Molecular Biology Reports},
  year={2014},
  volume={42},
  pages={907-915}
}
Stat3 alters the expression of its downstream genes and is associated with tumor invasion and metastasis in several human cancers. Its role in esophageal squamous cell carcinoma (ESCC) has not been well characterized. We examined the tumor sections of 100 cases of ESCC by immunohistochemistry and observed significant overexpression of Stat3 in the cytoplasm of 89 % of ESCC cells and of phosphorylated Stat3 (p-Stat3) in the nuclei of 71 % of ESCC when compare with normal esophageal mucosa (72… CONTINUE READING
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