Stat3 promotes directional cell migration by regulating Rac1 activity via its activator betaPIX.

@article{Teng2009Stat3PD,
  title={Stat3 promotes directional cell migration by regulating Rac1 activity via its activator betaPIX.},
  author={Terk Shin Teng and Baohong Lin and E. M. Manser and Dominic Chi Hiung Ng and Xinmin Cao},
  journal={Journal of cell science},
  year={2009},
  volume={122 Pt 22},
  pages={4150-9}
}
Stat3 is a member of the signal transducer and activator of transcription family, which is important for cytokine signaling as well as for a number of cellular processes including cell proliferation, anti-apoptosis and immune responses. In recent years, evidence has emerged suggesting that Stat3 also participates in cell invasion and motility. However, how Stat3 regulates these processes remains poorly understood. Here, we find that loss of Stat3 expression in mouse embryonic fibroblasts leads… CONTINUE READING