Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique C-terminal end.

@article{Huang2007Stat3IA,
  title={Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique C-terminal end.},
  author={Ying Huang and Jihui Qiu and Shuo Dong and Michele S Redell and Valeria Poli and Michael A. Mancini and David J Tweardy},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 48},
  pages={34958-67}
}
Two isoforms of Stat3 (signal transducer and activator of transcription 3) are expressed in cells, alpha (p92) and beta (p83), both derived from a single gene by alternative mRNA splicing. The 55-residue C-terminal transactivation domain of Stat3alpha is deleted in Stat3beta and replaced by seven unique C-terminal residues (CT7) whose function remains uncertain. We subcloned the open reading frames of Stat3alpha and Stat3beta into the C terminus of green fluorescent protein (GFP). Fluorescent… CONTINUE READING