Stat3 activation in human endometrial and cervical cancers

  title={Stat3 activation in human endometrial and cervical cancers},
  author={C Chen and F-C Hsieh and Jacqueline C Lieblein and J Brown and Claude Chan and Julie A. Wallace and Gong Cheng and Brent M. Hall and Jiayuh Lin},
  journal={British Journal of Cancer},
  pages={591 - 599}
The activation of signal transducer and activator of transcription 3 (Stat3) has been implicated in the oncogenesis of cancer and is regarded as a novel target for cancer therapy. Stat3 is classified as a proto-oncogene, because an activated form of Stat3 can mediate oncogenic transformation in cultured cells and tumour formation in nude mice. The constitutive activation of Stat3 has been frequently detected in various types of human cancers. However, the constitutive activation of Stat3 in… CONTINUE READING
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