Stat2-dependent regulation of MHC class II expression.

  title={Stat2-dependent regulation of MHC class II expression.},
  author={Wei Zhao and Edward N. Cha and Carolyn Lee and Christopher Y Park and Christian Schindler},
  journal={Journal of immunology},
  volume={179 1},
MHC type II (MHC II) expression is tightly regulated in macrophages and potently induced by IFN-gamma (type II IFN). In contrast, type I IFNs (IFN-Is), which are far more widely expressed, fail to induce MHC II expression, even though both classes of IFNs direct target gene expression through Stat1. The unexpected finding that IFN-Is effectively induce MHC II expression in Stat2(-/-) macrophages provided an opportunity to explore this conundrum. The ensuing studies revealed that deletion of… CONTINUE READING