• Biology, Medicine
  • Published in Cancer research 2003

Stat1-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand and the cell-surface death signaling pathway by interferon beta in human cancer cells.

@article{Choi2003Stat1dependentIO,
  title={Stat1-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand and the cell-surface death signaling pathway by interferon beta in human cancer cells.},
  author={Eugene A. Choi and Hanqin Lei and David J. Maron and James Meredith Wilson and James Barsoum and Douglas L. Fraker and Wafik S El-Deiry and Francis R. Spitz},
  journal={Cancer research},
  year={2003},
  volume={63 17},
  pages={
          5299-307
        }
}
Type I IFNs are known to inhibit tumor cell growth and stimulate the immune system. However, little is known of the mechanism of type I IFN-induced apoptosis in human cancer cells. In this study, we have IFN-beta treatment of a human colorectal cell line (KM12L4) and a resistant clone of this cell line, L4RIFN. We demonstrate the induction of apoptosis in the parent cell line. This process was associated with the induction of the Jak-Stat signaling pathway, induction of the proapoptotic… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 28 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

Inhibition of death receptor signals by cellular FLIP

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

How cells respond to interferons.

VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Biochemistry of interferons and their actions.

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL