Stat1 deficiency exacerbates carditis but not arthritis during experimental lyme borreliosis.

@article{Brown2006Stat1DE,
  title={Stat1 deficiency exacerbates carditis but not arthritis during experimental lyme borreliosis.},
  author={Charles R Brown and Victoria Blaho and Kevin L Fritsche and Christina M. Loiacono},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={2006},
  volume={26 6},
  pages={390-9}
}
Activation of the transcription factor Stat1 by interferon-gamma (IFN-gamma) is an important step in the development of antimicrobial effector mechanisms against many bacterial pathogens. Susceptibility to murine Lyme arthritis has been correlated with the production of several proinflammatory cytokines, especially IFN-gamma. To determine the role of IFN-mediated effector mechanisms in the development of Lyme borreliosis, we infected Stat1-deficient mice on both resistant (DBA), and susceptible… CONTINUE READING