Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma

@inproceedings{Dimberg2012Stat1AA,
  title={Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma},
  author={Lina Y. Dimberg and Anna I Dimberg and Karolina Ivarsson and M{\aa}rten Frykn{\"a}s and Linda Rickardson and Gerard Martin Tobin and Simon Ekman and Rolf Larsson and Urban Gullberg and Kenneth Nilsson and Fredrik B{\aa}ng {\"O}berg and Helena Jernberg Wiklund},
  booktitle={BMC Cancer},
  year={2012}
}
BackgroundMultiple myeloma (MM) is at present an incurable malignancy, characterized by apoptosis-resistant tumor cells. Interferon (IFN) treatment sensitizes MM cells to Fas-induced apoptosis and is associated with an increased activation of Signal transducer and activator of transcription (Stat)1. The role of Stat1 in MM has not been elucidated, but Stat1 has in several studies been ascribed a pro-apoptotic role. Conversely, IL-6 induction of Stat3 is known to confer resistance to apoptosis… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

STAT1 inhibits STAT3 activation in esophageal squamous cell carcinoma

  • Cancer management and research
  • 2018
VIEW 1 EXCERPT
CITES RESULTS

Neuroprotective effect of interleukin-6 in a rat model of cerebral ischemia.

  • Experimental and therapeutic medicine
  • 2015
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 55 REFERENCES

STAT1-induced apoptosis is mediated by caspases 2, 3, and 7.

  • The Journal of biological chemistry
  • 2004
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL